Anatomic Patterns of Relapse and Progression Following Treatment With 131I-MIBG in Metastatic Neuroblastoma
نویسندگان
چکیده
منابع مشابه
131I-MIBG in the diagnosis of primary and metastatic neuroblastoma.
OBJECTIVE Neuroblastoma is the third most common malignancy of childhood. 131I-MIBG scintigraphy must be performed in patients with neuroblastoma at the time of staging. The aim of this study is to identify the role of 131I-MIBG scintigraphy in neuroblastoma patients in correlation with other diagnostic modalities for staging of the disease. METHODS Twenty six patients provisionally diagnosed...
متن کاملComparing diagnostic performance of 131I-metaiodobenzylguanidine (131I-MIBG) and 99mTc-hydrazinonicotinyl-Tyr3-Octreotide (99mTc-HYNIC-TOC) in diagnosis and localization of pheochromocytoma and neuroblastoma
Introduction: The present study was aimed to assess the diagnostic performance of the two imaging methods of 131I-metaiodobenzylguanidine (131I-MIBG) and 99mTc-hydrazinonicotinyl-Tyr3-Octreotide (99mTc-HYNIC-TOC) in diagnosis and localization of pheochromocytoma and neuroblastoma. Methods: This study ...
متن کاملWhole-body dosimetry for individualized treatment planning of 131I-MIBG radionuclide therapy for neuroblastoma.
UNLABELLED The aims of this study were to examine the relationship between whole-body absorbed dose and hematologic toxicity and to assess the most accurate method of delivering a prescribed whole-body absorbed dose in (131)I-metaiodobenzylguanidine ((131)I-MIBG) therapy for neuroblastoma. METHODS A total of 20 children (1-12 y), 5 adolescents (13-17 y), and 1 adult (20 y) with stage 3 or 4 n...
متن کاملTumor response and toxicity with multiple infusions of high dose 131I-MIBG for refractory neuroblastoma.
BACKGROUND (131)I Metaiodobenzylguanidine ((131)I-MIBG) is an effective targeted radiotherapeutic for neuroblastoma with response rates greater than 30% in refractory disease. Toxicity is mainly limited to myelosuppression. The aim of this study was to determine the response rate and hematologic toxicity of multiple infusions of (131)I-MIBG. PROCEDURE Patients received two to four infusions o...
متن کاملIndividualized 131I-mIBG therapy in the management of refractory and relapsed neuroblastoma
OBJECTIVE Iodine-131-labelled meta-iodobenzylguanidine (I-mIBG) therapy is an established treatment modality for relapsed/refractory neuroblastoma, most frequently administered according to fixed or weight-based criteria. We evaluate response and toxicity following a dosimetry-based, individualized approach. MATERIALS AND METHODS A review of 44 treatments in 25 patients treated with I-mIBG th...
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ژورنال
عنوان ژورنال: International Journal of Radiation Oncology*Biology*Physics
سال: 2015
ISSN: 0360-3016
DOI: 10.1016/j.ijrobp.2015.07.469